https://www.mphartlab.com/home daily 1.0 2023-08-24 https://images.squarespace-cdn.com/content/v1/5d126b46818118000135f360/1568820964809-7LYONSC3YQH5W3V37YIY/banner1.jpg Home https://images.squarespace-cdn.com/content/v1/5d126b46818118000135f360/1566392388944-GDKHFKONG2FS5R8YPUY3/connectome2.jpg Home White matter pathways in human brain, ~90 billion neurons (adapted from humanconnectomeproject.org). Ball and stick model of every neuron in C. elegans, 302 neurons (openworm.org) https://images.squarespace-cdn.com/content/v1/5d126b46818118000135f360/1566392058075-GAGGD3TNXS72QTW7YL17/DVB+circuit+behavior.png Home One example of a ‘simple’ circuit - cartoon showing the DVB neuron and neurons/muscles it makes synaptic connections to that are involved in regulation of one step of the spicule protraction behavior, shown on right. https://images.squarespace-cdn.com/content/v1/5d126b46818118000135f360/3111d87e-3115-4e95-bc22-648bed15bc4c/Screen+Shot+2023-08-18+at+1.12.41+PM.png Home - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5d126b46818118000135f360/1ca7e3c4-be62-4a88-a092-894a95534271/Screen+Shot+2023-08-18+at+1.01.21+PM.png Home - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5d126b46818118000135f360/dffce9f3-40e1-482b-909b-973a0b8226d7/nlg-1-food-3.gif Home - Make it stand out on food baseline activity https://images.squarespace-cdn.com/content/v1/5d126b46818118000135f360/04c05a78-e53d-47b3-bb16-4f7a36dbad6f/nlg-1-no-food-3.gif Home - Make it stand out no food hyperactivity https://images.squarespace-cdn.com/content/v1/5d126b46818118000135f360/1566391928563-4EP91S1JE2XPJXVJVK1Q/nrxn+and+genes.png Home Cartoon showing a few synaptic proteins conserved from humans to C. elegans, including neurexins, neuroligins and shanks (all with multiple genes in humans and only a singular ortholog in C. elegans). Protein domain structure of three forms of human neurexin compared with the singular C. elegans ortholog, nrx-1. https://images.squarespace-cdn.com/content/v1/5d126b46818118000135f360/1562179242153-DHIGIHV3Y42M02TXB9TX/HartLogo+copy.gif Home - Seeking candidates for graduate and undergraduate positions - see contact page https://www.mphartlab.com/publications daily 0.75 2026-03-30 https://images.squarespace-cdn.com/content/v1/5d126b46818118000135f360/1562163023042-L8S6EOSX6WAU0JL5X8H8/HartLogo+copy.gif Publications - Click Here for PubMed list of all publications https://www.mphartlab.com/labmembers daily 0.75 2025-09-02 https://images.squarespace-cdn.com/content/v1/5d126b46818118000135f360/a5acd6b6-5910-4a4f-9432-8295d783d8bf/IMG_9708.jpg Lab Members - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5d126b46818118000135f360/944fe82f-e465-46b0-8c15-1a89bcce8639/IMG_1521.jpg Lab Members - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5d126b46818118000135f360/9bddbe97-827c-44ff-abae-e143938caa78/IMG_5280.jpg Lab Members - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5d126b46818118000135f360/2d04ae49-82d9-4928-bfed-d8d2f3dbcd9c/Hart+MP.jpg Lab Members https://images.squarespace-cdn.com/content/v1/5d126b46818118000135f360/1596059112741-Y5EUAAT66VL2DEWI9EEW/Screen+Shot+2020-07-29+at+5.32.05+PM+copy.png Lab Members Artist: Daniel Quasar https://images.squarespace-cdn.com/content/v1/5d126b46818118000135f360/ad8bde33-aaa0-4b86-87a8-f1f028b46080/Dustin_profile.jpg Lab Members - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5d126b46818118000135f360/1d604300-b29b-458c-9905-32a9c97c8d6d/PXL_20231229_192930113%7E2.jpg Lab Members https://images.squarespace-cdn.com/content/v1/5d126b46818118000135f360/1606930554986-SIT4O9UVT3PJWAFIGG0Y/profile+picture.png Lab Members https://images.squarespace-cdn.com/content/v1/5d126b46818118000135f360/edfdfa87-58ed-4e16-98e2-8242c6a5042d/IMG_7958+%281%29.jpg Lab Members - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5d126b46818118000135f360/c83bc5e2-4de1-4ce3-89a7-f0c271f8a165/Screen+Shot+2023-08-23+at+4.59.56+PM.png Lab Members - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5d126b46818118000135f360/43dad395-4d0e-4d69-a28d-785a9fa1d687/DSC_0429.JPG Lab Members - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5d126b46818118000135f360/432937ca-3e40-4e25-8535-cceaf230ba4e/img_2987_720.jpg Lab Members - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5d126b46818118000135f360/84153165-e3ef-44d0-a30a-a0552f5e0b6d/Screen+Shot+2024-03-04+at+12.44.52+PM.png Lab Members - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5d126b46818118000135f360/cc6f2edc-d159-428f-9213-9a80c0b5f13c/jhelaine+palo+4.jpg Lab Members - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5d126b46818118000135f360/8df0cf07-051f-4026-8503-f6ab889c4052/6DD81545-057C-419C-90E4-B796C10F2201+%281%29.jpg Lab Members - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5d126b46818118000135f360/1566409299113-RR5FPAXOZSWJBTY8GCQU/elegansgif.gif Lab Members https://images.squarespace-cdn.com/content/v1/5d126b46818118000135f360/1596057393212-EAH7NWO8JGS7T3VIF9CG/image0.jpg Lab Members Artist: Sammy Katta - https://sammykatta.com/diversity https://images.squarespace-cdn.com/content/v1/5d126b46818118000135f360/124a3de2-b520-460d-b869-aa1be9199fd3/IMG_0040.jpg Lab Members - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5d126b46818118000135f360/3ef39f25-39eb-4942-a724-1f333488ebfc/lab+summer+2021.png Lab Members - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.mphartlab.com/contact-us daily 0.75 2024-11-11 https://www.mphartlab.com/research daily 0.75 2023-08-18 https://images.squarespace-cdn.com/content/v1/5d126b46818118000135f360/1561579898271-CTX4YJ19KPGJ68YAI2VI/website5.jpg Research https://images.squarespace-cdn.com/content/v1/5d126b46818118000135f360/1566393865669-5H3J4PLW329R7BPG3QVK/DVB+circuit+etc.png Research Cartoons of DVB neuron in each sex of C. elegans, with wiring diagram of DVB synaptic connections within each respective sex-specific circuit based on EM reconstruction (wormwiring.org). https://images.squarespace-cdn.com/content/v1/5d126b46818118000135f360/1566416906762-FC6BMEUXTB9I53N3NXPU/dvb+time-01.png Research The GABAergic DVB neuron in males at day 1, 3, and 5 of adulthood showing progressive neurite outgrowth (arrows)(lim-6::wCherry), with new neurites making additional pre-synaptic connections (lim-6::gfp::rab-3). https://images.squarespace-cdn.com/content/v1/5d126b46818118000135f360/1566395835239-QPJL9K70E60HLFG4BR5Z/newfig1-01.png Research C. elegans can be utilized as a model to study how mutations in autism-associated gene orthologs may impact DVB neuron morphology and circuit plasticity, as well as behavioral phenotypes that implicate additional functions in novel neuronal circuits. https://images.squarespace-cdn.com/content/v1/5d126b46818118000135f360/1562174122064-I9FZFUMAXLBQIQ7L4F91/HartLogo+copy.gif Research - 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ELEGANS POPULATIONS (LEFT AND RIGHT) AND SYNAPSES (CENTER). https://images.squarespace-cdn.com/content/v1/5d126b46818118000135f360/9a3b16d2-5787-4ae9-b673-5d7b7e2b797d/KZ2024.png SciArt KZ2024 (MPH). METAL PLATE CUTOUT OF A CONFOCAL STACK TAKEN OF THE DVB NEURON MOUNTED ON WOOD PANEL. https://images.squarespace-cdn.com/content/v1/5d126b46818118000135f360/f1e025b5-2ecd-4768-9afb-b16fea70cbb2/Vote+square.png SciArt - Make it stand out VOTE (MHC). Acrylic on paper. https://images.squarespace-cdn.com/content/v1/5d126b46818118000135f360/06e38a56-c337-421d-bcf2-18b757f97adc/BLB2024+1.png SciArt - Make it stand out BLB2024 (MPH). Photo prints on foam board with relief and sunken C. elegans with neurons from confocal image of nrx-1 expression. Repeating patterns made from octopamine chemical structure or WorMotel image. https://images.squarespace-cdn.com/content/v1/5d126b46818118000135f360/72fe519a-db32-498c-92bf-5fee5992d6a6/BLB2024+2.png SciArt - Make it stand out BLB2024 (MPH). 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